Bioactive Small Molecules
Medchemexpress LLC Fluopyram technical | 658066-35-4 | 99.8% | 100MG
Fluopyram technical | 658066-35-4 | 99.8% | 100MG
Medchemexpress LLC Lanuginosine | 23740-25-2 | 98.3% | 5 MG
Lanuginosine is an aporphine alkaloid research compound with reported biological activities including apoptosis induction, acetylcholinesterase (AChE) inhibition (IC50: 10.9 μM), and inhibition of Aβ aggregation. It is used in anticancer and Alzheimer's disease research.
- Alkaloid research compound with formula C18H11NO4.
- Molecular weight 305.28 g·mol⁻1.
- Purity 98.3% (as listed).
- Reported activities include apoptosis induction, AChE inhibition (IC50: 10.9 μM), and inhibition of Aβ aggregation.
- Supplied as a 5 mg pack for research use.
Medchemexpress LLC Promegestone (R-5020) | 34184-77-5 | 99.1% | 5 MG
Promegestone (R-5020) is a synthetic progestin and potent progesterone receptor agonist used as a research tool for studies of progesterone signaling, endocrine regulation, and cancer biology.
- Potent progesterone receptor (PR) agonist for receptor biology studies.
- Synthetic steroid with molecular formula C22H30O2 and molecular weight 326.47 g/mol.
- Supplied as a solid suitable for in vitro and in vivo research applications.
- Typical purity reported around 98.0% by supplier certificate of analysis.
- Useful as a pharmacological probe in endocrine and cancer research models.
Cayman Chemical ANTIBODY Myr-ZIP 10mg
A PKMζ inhibitor (Ki = 0.076-2.11 µM); inhibits PKCα at 10 µM; prevents ionomycin-induced PKC translocation to the plasma membrane in HEK293 cells expressing AKAP79 at 5 µM; inhibits the conditioned place preference response to morphine in rats when administered intracranially into the nucleus accumbens core at doses of 10 and 30 nmol/0.5 µl per side
Cayman Chemical nuropeptIde EIratrIflu 5mg
An endogenous peptide fragment of rat prepro-MCH; expressed in both the central and peripheral nervous systems, localizes to the cytoplasm, and colocalizes with MCH in the CNS; reduces TRH release in mediobasal hypothalamus explants at 1 µM; increases serum levels of LH in male rats and in chronically ovariectomized female rats that received estradiol benzoate and progesterone in addition to NEI; induces excessive grooming behavior and increases locomotor activity in rats at 1 UG/animal; increases the amount of time spent in REM sleep in rats when injected intracerebroventricularly or into the vlPAG
Cayman Chemical ANTIBODY LIpId 5 10mg
An ionizable cationic lipid (pKa = 6.56); has been used in the generation of LNPs for the delivery of mRNA in vitro and in vivo; intravenous administration of LNPs containing lipid 5 and encapsulating mRNA encoding hEPO increase serum hEPO levels in cynomolgus monkeys
Cayman Chemical ANTIBODY AZD 5462 10mg
An RXFP1 agonist; induces cAMP mobilization in HEK293 cells expressing the human RXFP1 (EC50 = 15.85 nM); increases heart rate and MABP in rats; increases the left ventricular ejection fraction (LVEF) in a cynomolgus monkey model of heart failure induced by a high-fat diet and age at 1 or 10 mg/kg per day
Medchemexpress LLC HY-U00137 1mg Medchemexpress, YS-201 CAS:108852-42-2 Purity:>98%
Medchemexpress, HY-U00137 1mg YS-201 CAS:108852-42-2 YS-201 is a dihydropyridine-type calcium channel antagonist previously in clinical trials for the treatment of angina pectoris and hypertension. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical Garenoxacn 5mg
A quinolone antibiotic; active against a variety of Gram-positive and Gram-negative bacteria (MIC90s = 0.025-6.25 and 0.0125-100 UG/ml, respectively); inhibits E. coli DNA gyrase supercoiling and S. aureus topoisomerase IV decatenation activities (IC50s = 0.17 and 2.19 mg/L, respectively); selective for S. aureus topoisomerase IV over human topoisomerase II (IC50 = 509.7 UG/L); efficacious against systemic quinolone-resistant S. aureus infection and pneumonia induced by the penicillin-resistant S. pneumoniae clinical isolate D-979 in mice (ED50s = 0.0189 and 0.0278 mg/animal, respectively)
Medchemexpress LLC GPR17 antagonist 1 | 1574405-61-0 | 99.0% | 384.86 | 5 MG
GPR17 antagonist 1 (compound 978) is a GPR17 antagonist used in the study of diabetes and obesity.
- GPR17 antagonist
- Used in diabetes and obesity research
- High purity of 98.95%
- CAS number: 1574405-61-0
- Molecular weight: 384.86
- Solid, white to off-white appearance
- Soluble in DMSO for in vitro studies
- Soluble in 10% DMSO and 90% corn oil for in vivo studies
- Targets transmembrane glycoprotein
- Relevant to immunology and inflammation pathways
- Stable as powder for up to 3 years at -20°C
- Stable in solvent for up to 6 months at -80°C
Medchemexpress LLC Abc99 | 2331255-53-7 | 98.5% | 1 MG
ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50 13 nM) and preserves Wnt3A signaling in the presence of NOTUM.
- Selective NOTUM inhibitor with IC50 of 13 nM.
- Preserves Wnt3A signaling in the presence of NOTUM.
- Molecular formula C22H21ClN4O5; molecular weight 456.88.
- Purity 98.5% with supporting analytical documentation (COA, H NMR, LCMS, SDS).
- Available as a 1 mg solid and as a 10 mM solution in DMSO.
Medchemexpress LLC Deltasonamide 1 | 2088485-33-8 | 99.2% | 10 MG
Deltasonamide 1 is a small-molecule inhibitor of PDE6δ-KRas with high affinity (KD ≈ 203 pM) and is supplied for research applications, including tumor research. It is provided as a solid and in DMSO solution formulations with recommended storage guidance.
Medchemexpress LLC MCHR1 antagonist 2 | 863115-70-2 | MFCD30533356 | 98.3% | 424.42 g/mol | C23H21FN2O5 | 10 MG
MCHR1 antagonist 2 is a small-molecule antagonist of the melanin-concentrating hormone receptor 1 (MCHR1) that shows nanomolar potency in biochemical and cellular assays and documented hERG activity. It is supplied as a solid with high reported purity for research applications.
- Antagonist of MCHR1 with IC50 65 nM.
- Inhibits hERG with IC50 4.0 nM in IMR-32 cells.
- Inhibits MCH-mediated Ca2+ flux in FLIPR assay (IC50 ≈196 ± 30 nM).
- High purity (98.3%) suitable for biochemical assays.
- Chemical formula C23H21FN2O5; molecular weight 424.42 g/mol.
- CAS number 863115-70-2 for unambiguous identification.
![Medchemexpress LLC N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]pyridine-3-carboxamide | 496793-75-0 | 99.9% | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230447.png-250.jpg)
Medchemexpress LLC N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]pyridine-3-carboxamide | 496793-75-0 | 99.9% | 100 MG
AZSMO-23 (CAS 496793-75-0) is a small-molecule activator of the hERG (Kv11.1) potassium channel used for in vitro electrophysiology and pharmacology research. It activates wild-type hERG pre-pulse and tail currents with reported EC50 values of 28.6 μM and 11.2 μM, respectively. Supplied as an off-white to light yellow solid with high purity and defined storage recommendations.
- High purity: 99.9%.
- Molecular formula C19H13ClN4O; molecular weight 348.79 g/mol.
- Potent hERG K+ channel activator; EC50 28.6 μM (pre-pulse), 11.2 μM (tail).
- Soluble in DMSO (~5.83 mg/mL) with ultrasonic warming recommended.
- Appearance: off-white to light yellow solid.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months).