Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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5,281 – 5,295 of 60,541 results

5,281

Selleck Chemical LLC Pexidartinib Hydrochloride E6007-1G

Pexidartinib Hydrochloride is an oral tyrosine kinase inhibitor of colony-stimulating factor 1 receptor (CSF1R) It significantly reduces macrophage levels in adipose tissue without altering overall myeloid cell counts in mice It also induces developmental and immunotoxic effects in zebrafish embryos by hyperactivating Wnt signaling

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5,282

TARGETMOL CHEMICALS INC BMS-794833 10MG

Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2; a prodrug of BMS-817378. purity: 99%

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5,283

TARGETMOL CHEMICALS INC YNT-185 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. YNT-185 is a nonpeptide selective agonist of the orexin type-2 receptor (OX2R) demonstrating EC50 values of 0.028 uM and 2.75 uM for OX2R and OX1R respectively. Furthermore YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models. purity: 98%

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5,284

eMolecules 788146-37-2 | SY-21 NHS ester | Broadpharm815.340 | C45H39ClN4O7S | 0.000 | [Cl-].O=C(ON1C(=O)CCC1=O)C1CCN(CC1)S(=O)(=O)c1ccccc1-c1c2ccc(cc2oc2c\c(ccc12)=[N+]1/CCc2ccccc12)N1CCc2ccccc12 | 5mg | 713699975

SY-21 NHS ester | Broadpharm | 788146-37-2815.340 | C45H39ClN4O7S | 0.000 | [Cl-].O=C(ON1C(=O)CCC1=O)C1CCN(CC1)S(=O)(=O)c1ccccc1-c1c2ccc(cc2oc2c\c(ccc12)=[N+]1/CCc2ccccc12)N1CCc2ccccc12 | 5mg | 713699975

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5,285

Medchemexpress LLC (S)-XY-05 | 3024030-10-9 | 99.8% | 447.41 g·mol⁻¹ | C20H20F3N7O2 | 10 MG

PARP7-IN-17 is a potent small-molecule inhibitor of PARP7 with an IC50 of 4.5 nM. It demonstrates oral bioavailability and reported antitumor activity. Supplied as a white to off-white solid for research use, it is commonly used in cellular and in vivo studies of PARP7 biology and anticancer mechanisms.

Potent PARP7 inhibition (IC50 4.5 nM).
Reported oral bioavailability and antitumor activity.
High purity (≈99.8%) suitable for research applications.
Solid, white to off-white appearance for ease of handling.
Recommended storage: powder -20°C (up to 3 years) or 4°C (up to 2 years).
Available in small milligram pack sizes for preclinical studies.

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5,286

Medchemexpress LLC Simufilam (PTI-125) | 1224591-33-6 | 99.8% | 259.35 | 1 ML

Simufilam (PTI-125) is an orally active FLNA modulator. It restores NMDAR signaling and Arc expression, inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, and reduces Aβ42-induced neuroinflammation and tau protein hyperphosphorylation. This modulator can be used for research of Alzheimer's disease.

Restores NMDAR signaling and Arc expression
Inhibits overactive mTOR signaling
Improves insulin sensitivity
Reduces Aβ42-induced neuroinflammation
Reduces tau protein hyperphosphorylation

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5,287

Medchemexpress LLC 5'-O-TBDMS-Bz-dA | 51549-39-4 | 98.37% | 469.61 | 1 ML

5'-O-TBDMS-Bz-dA is a nucleoside that acts as a protective and modification agent. This white to off-white solid is for research purposes only, not for human use.

Protective and modification effects
Used in DNA/RNA synthesis research
Classified as a nucleoside analog and adenosine derivative
Related to cancer, blood, and cardio-cerebrovascular disease research
Soluble in DMSO: 100 mg/mL
Formulatable for in vivo experiments

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5,288

eMolecules 41797-88-0 | ChemScene | 233-Trimethyl-3H-indol-5-ol | 100mg | 768994307 | CS-0617004 | 175.231 | C11H13NO

Medchem Express | Osilodrostat | 2mg | 446267317 | HY-16276 | 928134-65-0 | MFCD25976825 | 227.242 | C13H10FN3

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5,289

Cayman Chemical CVT-12012, Purity: ≥98%, CAS: 1018675-35-8, 25 mg

An SCD inhibitor (IC50 = 6.1 nM in HepG2 cells); dose-dependently reduces levels of palmitoleic acid and vaccenic acid in the plasma and liver of rats fed a high-sucrose diet; reduces hepatic triglyceride levels in sucrose-fed rats at 20 mg/kg

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5,290

Medchemexpress LLC Cxcr2 antagonist 8 | 182498-30-2 | 98.38% | 303.27 | 5 MG

CXCR2 antagonist 8 is a potent and selective CXCR2 antagonist. It can be used for insulin resistance research.

Potent and selective CXCR2 antagonist
Used for insulin resistance research

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5,291

Medchemexpress LLC Atg7-IN-2 | 2226227-75-2 | 99.3% | 376.35 | 50 MG

ATG7-IN-2 (compound 1) is a potent ATG7 inhibitor, with an IC50 of 0.089 μM. It inhibits the autophagy marker LC3B. This product is for research use only and is not sold to patients.

Potent ATG7 inhibitor with an IC50 of 0.089 μM.
Inhibits autophagy marker LC3B.
Inhibits the formation of the ATG7-ATG8 thioester in HEK293 cells with an IC50 of 0.335 μM.
Suppresses LC3B lipidation in H4 cells with an IC50 of 2.6 μM.
Reduces cell viability in H1650 cells with an EC50 of 2.6 μM.

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5,292

Cayman Chemical 3,4-trimethylene-α-Piperidinovalerophenone (hydrochloride), Purity: ≥98%, 5 mg

An analytical reference standard categorized as a cathinone; intended for research and forensic applications

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5,293

Medchemexpress LLC Stearoyl glutamic acid sodium | 38517-23-6 | C23H42NNaO5 | 500 MG

Stearoyl glutamic acid sodium, also known as Sodium stearoyl glutamate, is an anionic emulsifier suitable for cosmetic applications. It also functions as an anionic surfactant and an amino acid alkyl amide sensitizer, which may potentially lead to allergic contact dermatitis.

Anionic emulsifier for cosmetics.
Functions as an anionic surfactant.
An amino acid alkyl amide sensitizer.

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5,294

Cayman Chemical Rosavin, Purity: ≥98%, CAS: 84954-92-7, 5 mg

A diglycoside with diverse biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 5.86 µg/ml); inhibits the proliferation of NCI H69, NCI H526, and NCI H446 SCLC cells at 5-100 µM; inhibits concanavalin A- or anti-CD3 and anti-CD28 antibody-induced growth of Jurkat T cells (IC50s = 80 and 74 µM, respectively) and reduces TRAIL levels in isolated mouse splenic T cells at 0.5, 5, and 50 µM; reduces ferroptosis-related mitochondrial changes and increased levels of 4-HNE and MDA in type II alveolar epithelial cells, as well as reduces lung tissue iron levels, in a rat model of intratracheal PM2.5-induced lung injury at 100 µM

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5,295

Medchemexpress LLC GPR84 antagonist 2 | 2244269-74-5 | 99.06% | C28H16Cl2NaO4PS2 | 1 ML

GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). It demonstrates improved potency in calcium mobilization assays and inhibits neutrophil and macrophage chemotaxis upon GPR84 activation, showing potential for ulcerative colitis research.

Potent and selective GPR84 antagonist
Orally active with an IC50 of 8.95 nM
Improves potency in calcium mobilization assays
Inhibits neutrophil and macrophage chemotaxis
Potential for ulcerative colitis research
Solid storage: -20°C, sealed, away from moisture
In solvent storage: -80°C for 6 months; -20°C for 1 month, sealed, away from moisture

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Bioactive Small Molecules

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Medchemexpress LLC (S)-XY-05 | 3024030-10-9 | 99.8% | 447.41 g·mol⁻¹ | C20H20F3N7O2 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Simufilam (PTI-125) | 1224591-33-6 | 99.8% | 259.35 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 5'-O-TBDMS-Bz-dA | 51549-39-4 | 98.37% | 469.61 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Cxcr2 antagonist 8 | 182498-30-2 | 98.38% | 303.27 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Atg7-IN-2 | 2226227-75-2 | 99.3% | 376.35 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Stearoyl glutamic acid sodium | 38517-23-6 | C23H42NNaO5 | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC GPR84 antagonist 2 | 2244269-74-5 | 99.06% | C28H16Cl2NaO4PS2 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More